Chronic Fatigue Syndrome
Symptoms of Chronic Fatigue Syndrome
There are three major signs and ten supporting symptoms associated with
this condition. According to criteria developed in Australia, the diagnosis
can be made on the presence of two major together with five supporting
symptoms. These are:
Major: Persisting generalised fatigue, lasting more than six months made
worse by minor exercise.
Symptoms of reduced brain function such as impaired concentration or
memory.
Abnormalities in immune function involving reduced number of specific
white blood cells.
Minor: Muscle pain; muscle tenderness; joint pain; headaches; depression;
tinnitus; insomnia;
swollen lymph glands; recurrent laryngitis; irritable bowel syndrome.
Symptoms often follow a viral infection but there is not always a clear
trigger.
Diagnosis of Chronic Fatigue Syndrome / ME
There have been many attempts to develop a blood test to confirm the diagnosis of CFS but this has not been possible. The serological evidence of infection by a coxsackie virus is only present in a small number of patients and it is now felt that there are many possible viral triggers and glandular fever or a ‘flu’-like illness is often seen prior to the onset of symptoms. Many patients do not have a clear history of previous infection but a lot appear to be high achievers who have pushed themselves too hard. A number of nutritional deficiencies can be detected and low levels of magnesium are commonly found. In summary, a viral screen, differential white cell count and red cell magnesium are useful supportive investigations. Other tests for abnormal responses by the adrenal glands and the serotonin receptors in the hypothalamus are used in specialist units.
